(RSNA 2018, Wed Nov 28 2018 11:30AM - 11:40AM ROOM Z41) PURPOSE To objectively evaluate the impact of Compressed-SENSE (CSENSE), a novel acquisition technique that combines compressed sensing with parallel imaging (or SENSE), on acquisition time and image quality in MR imaging of the spine. METHOD AND MATERIALS Current standard of care clinical axial T1 and T2-weighted acquisitions of the cervical and lumbo-sacral spine were modified to obtain higher acceleration with CSENSE (CSENSE factor 1.3999). Twenty-six patients were scanned both, with and without CSENSE, on a 3.0 T wide-bore MRI (Ingenia, Philips Healthcare). The images were anonymised and shared with three specialist MRI radiologists blinded to the acquisition type. Both sets of images were rated on a scale of 1 to 5 for image quality and delineation of specific structures including vertebral bodies, lateral recess, neural foramina, facet joints, cauda equina, nerve roots, spinal cord and paraspinal muscles. Disc abnormalities, foraminal stenosis, nerve root compression and facet joint degeneration were also rated. Dicom metadata was analysed to assess scan time acceleration (ratio of original time to CSENSE time). RESULTS Interrater agreement on image quality was compared between the Normal and CSENSE scans via a multivariate non-parametric Hotelling's T2 test. There was no statistically significant difference between Normal and CSENSE scans in the 12 measures evaluated by each radiologist (alpha < 0.001 level). Further, the mean percentage observed agreement between Normal and CSENSE scans for all three measures across the radiologists was 93%. The average time acceleration achieved using CSENSE on axial T1 was 1.41 and on axial T2 was 1.36 and the average time saved was 58 seconds (29%) and 50 seconds (26%) respectively. CONCLUSION There is no difference in image quality between current standard of care and CSENSE-based T1 and T2 axial MRI scans of the spine. Compressed-SENSE in the spine can reliably replace current axial T1 and T2 acquisitions without loss in image quality and with significant reduction in scan time. CLINICAL RELEVANCE/APPLICATION The potential for CSENSE to accelerate MRI acquisition without hampering image quality will increase patient throughput and patient compliance in MR scanning.